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Co-administration of chloroquine and coenzyme Q10 improved treatment outcome during experimental cerebral malaria

Bosire Ouko, Nyabuga James Nyariki, Peninah Wairagu

Abstract

Development of cerebral malaria (CM) is driven by parasitemia levels, harmful inflammatory response, oxidative stress and consequent breach of the blood brain barrier. Use of adjunct therapy that utilizes an antioxidant and anti-inflammatory agent alongside chloroquine (CQ), may improve treatment outcome and shorten recovery from post-infection sequelae. Though withdrawn in some countries, CQ is still in use for prophylaxis and treatment of malaria in many countries.

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Ouko, D.B., Amwayi, P.W., Ochola, L.A. et al. Co-administration of chloroquine and coenzyme Q10 improved treatment outcome during experimental cerebral malaria. J Parasit Dis (2022). https://doi.org/10.1007/s12639-022-01468-4

Bosire Ouko, Nyabuga James Nyariki, Peninah Wairagu

2) Yimin Yan, Oduor A. M. O, Feng Li, Yonghong Xie, and Yanjie Liu (2022). Opposite effects of nutrient enrichment and an invasive snail on the growth of invasive and native macrophytes. Ecological Applications (In press).

2) Yimin Yan, Oduor A. M. O, Feng Li, Yonghong Xie, and Yanjie Liu

1) Oduor, A. M. O., Adomako M.O., Yuan Y., and Li, JM (2022). Older populations of the invader Solidago canadensis exhibit greater positive plant-soil feedbacks and competitive ability in China. American Journal of Botany. doi.org/10.1002/ajb2.16034.

Ayub M.O. Oduor, Michael Opoku Adomako, Yongge Yuan, Jun-Min Li